The Defenders is a Netflix exclusive television series set in the Earth-11584 universe of the Marvel Cinematic Universe. It is a culmination of several such shows, bringing together various heroes such as Daredevil, Luke Cage, Iron Fist and Jessica Jones. It also stars Benedict Cumberbatch and Chiwetel Ejiofor from the Doctor Strange film, as well as Gina Carano from other various Marvel properties as the She-Hulk. In the series, the individual heroes must band together despite their differences to stop the attempted interdimensional incursion of Blackheart and his father, the Faltine Demon Mephisto.
Throughout the ages, history has called upon great men and women to step up to the challenges of their time. To be the great heroes of legend and fight back against the forces of evil that would threaten to destroy civilization. These titans of myth were unto gods cast into the edifice of time like marble statues, wholly without flaw. Unfortunately, history doesn't have those people. Instead four very different heroes have to join forces to save the city of New York, if they don't destroy each other first.
Episode 1. The Tides of War
We open on a back alley in New York City, near the medical facility built in the Flatbush neighborhood. A hooded homeless man warms himself near a fire when he is approached by Mr. Degli, who offers him a warm place to stay for the night if he'll agree to a simple experiment. The man agrees and Degli takes him into a warehouse, where Karl Mordo is waiting.
We cut to Danny Rand and Colleen Wing, the two people with the power of the Iron Fist, traversing the mountains of Tibet in search of the gate of K'un-Lun, only for them to be intercepted by, surprisingly enough, Doctor Strange, who tells them not to act impulsively and open up the gate the great evil. Rand argues with Strange, but the Sorcerer Supreme is insistent, saying that K'un-Lun being locked away right now is the only hope they have to protecting not only the Earth, but all of creation, as he leads them back to the Sanctum Sanctorum.
On the streets of New York, Matt Murdock is maintaining his double life as both the Devil of Hell's Kitchen as well as a lawyer helping the downtrodden. However, Matt's double life has been quieter as of late, due to pressure put on by the NYPD. He and his partner, Foggy Nelson, discuss these things in his loft apartment, with Nelson saying that they are close to finding connecting information that proves that Wilson Fisk is the Kingpin of Crime in New York City. As they leave for a court date, the conversation turns to the missing Luke Cage, a former client of there's, following the events of the Harlem riots. Unbeknownst to them (or at least Foggy, as Matt appears to know he's being followed), Manhattan private investigator Jessica Jones slowly tails them at the behest of an unknown benefactor. Her sojurn is interrupted by a phone call from her sister, asking to meet her that night as she has something to discuss with her. Jessica agrees, but asks that it be at a "dive in Hell's Kitchen", as she's working on a case. Trish reluctantly agrees, after complaining about how she can't really hold her liquor.
In Harlem, Claire Temple is arriving home after finishing her shift at the hospital, and we see that her new townhouse has gotten something of an upgrade in recent years, as there are medical supplies strewn about everywhere. She is visited by former NYPD detective Misty Knight, who tells asks her how "business has been going" since the Harlem Riots, which Claire states as steady. Running a free clinic out of her townhouse isn't the easiest thing in the world, but she gets by as best she can. Knight invites her to a vigil that night in recognition for the Hero of Harlem, but Claire still holds out hope for his return. As we get a closeup shot of Luke's picture on the wall, we transition to him inside an undisclosed location, unresponsive and still under the control of Kevin Killgrave. Mr. Degli, also known as Blackheart, who directs Killgrave to send Cage and Elektra on a mission to acquire a relic from the Sanctum Sanctorum, a spell that can only be found in the mystical Book of the Vishanti. To get in though, they'll need Mordo and the Wand of Watoomb, though Degli doesn't know where they've gone. As he leaves, Killgrave sends Cage on his mission, though tells Elektra he needs her somewhere else. We then cut to Mordo testing out his power with the wand, as we replay the end credits scene from Doctor Strange where he strips Jonathan Pangborn of his magic. After Mordo departs, Pangborn struggles to call for help, asking a person who wanders into his shop to dial an unknown number on his phone.
That night, inside Josie's Bar in Hell's Kitchen, Jessica and Trish meet up, with Trish (who is already slightly inebriated) explaining that she apparently has gained super powers, namely enhanced reflexes and speed, as a delayed reaction to the treatments that they had as children. Jessica is at first unimpressed by this (even more so when Trish insists on trying to fight crime with her), and tries to discourage anything that would draw attention to Trish, though it's clear she doesn't really believe her adopted sister. She trails off when Matt Murdock comes into the bar, alone. She starts to leave, but Matt walks right up to her (surprisingly, from Jessica's point of view) and tells Jessica to "quit stalking him." Jessica tries to deny this, but the drunken Trish spills the beans about Jessica being hired to find blackmail material on the blind lawyer. Jessica shakes her head and leads Trish away, causing her to complain about not being finished with her drink. Outside, a still drunken Trish apologizes, but Jessica says she can make it up to her later.
Sometime later, Matt is heading home when he hears a commotion outside his apartment building. Throwing a ski mask on he heads into an alley, only to find a still drunken Trish tied up to the fire escape. He helps her down and asks her what happened, but Trish feigns ignorance (though not well, given her inebriated state.) Matt looks upward and sees the fire escape to his apartment having been used, and he quickly jumps up to the rooftop and finds his way in, only to be confronted by Jessica Jones holding up his Daredevil cowl, saying if he wants to explain himself.
Episode 2. Shaolin Brew
Matt is obviously taken aback by Jessica's sudden appearance and confirmation that he is the "Devil of Hell's Kitchen", but he tries to turn the subject to who hired Jessica in the first place. Jessica doesn't reveal anything, and tells Matt she finds the whole super hero routine to be overrated. She threatens to take the information directly to the police, but Matt returns that he could ask the same thing about her own abilities, causing Jessica to raise an eyebrow at how he knows about her. Matt suddenly stops playing coy with her, though, and yells out to someone else to come out of the shadows. Jessica says she is here alone, but is surprised when Stick comes out, saying he's been here ten minutes longer than she had. Stick and Matt argue with each other (much to Jessica's annoyance), with Matt telling him he wants nothing more to do with him and Stick trying to warn him about something coming. Stick finally drops a bombshell that causes Matt to stop his arguing, informing him that Elektra is once again alive, resurrected by the "substance" of the Hand. Matt says he thought he had heard the Hand was destroyed, which Stick seemingly confirms, only to say Elektra is working with some guy named Degli, which draws Jessica's interest. They agree to sit down and compare what they know, Matt putting on a pot of coffee while Jessica brings her drunk and passed out sister inside to the apartment (keeping Matt's Daredevil mask as insurance to him not running off.)
Inside the Sanctum Sanctorum, Danny and Colleen are led in by Doctor Strange, Danny commenting that the monks at K'un-Lun told him of the Sanctum and its importance (Strange is unamused, simply telling him not to touch anything.) He briefly re-explains the origins of K'un-Lun as a dimensional nexus, and states that the Faltine Demon Mephisto is attempting to enter the realm of Earth to conquer K'un-Lun, which would give him access to virtually the entirety of the Cosmos instantaneously. Before he can explain further, Wong tells him he's received a phone call from Pangborn, causing Strange to leave the two Iron Fist warriors in Wong's care, reiterating them to touch nothing. Back at Pangborn's shop, Strange rushes in and finds Pangborn on the floor, unable to use his arms or legs. Strange tries to ascertain the cause, when he is interrupted by Mordo. The two trade banter in the shop, Mordo stating that it is not just sorcerers who pervert the natural law, but the whole of humanity. That the Faltine should have been victorious in the war with the Celestials, and that Mephisto will make things right. The two fight briefly, trading spells evenly. Mordo eventually catches Strange off guard with the Wand of Watoomb, attempting to drain his magic the same way he had done to Pangborn. However, Strange smiles at him and tells him that he wouldn't have come there into a trap, revealing that the Strange who fights is just an illusion, frustrating Mordo. We cut back to the Sanctum Sanctorum, seeing Strange meditating in front of his window, Eldritch magic sparking off of him. Danny and Colleen look on with awe, Wong trying to explain what is happening. But that is interrupted by banging at the Sanctum door. Wong says that the defenses of the building will protect them, but the banging continues. As they look out the window, they see Luke Cage trying in vain to break through the barriers within. Danny says he recognizes him, and before Colleen can stop him goes out to try and talk sense into him.
We cut back to Matt's apartment, where Stick and Matt explain briefly the concepts of The Hand to Jessica Jones. Jessica can hardly believe what they are telling her, but admits that she has seen stranger things. She also says that explains how Degli is alive, given how she discovered he should have died years ago, but Stick can't help but feel that there's something more to this with him. Matt however still can't believe that Elektra is alive, and that even if she was she would never willingly help the Hand. Jessica, in her smart alecky way, says that maybe he didn't know her as well as he thought, and Matt nearly loses his temper, switching the subject back to why she broke into his apartment in the first place. Stick tells them to calm down when he hears something outside on the rooftop, and the three of them (Jessica disbelieving that he can hear things that well, despite both he and Matt confirming that something is out there) go outside to investigate. There, Jessica is flabbergasted when she sees Kevin Killgrave, alive and flanked by Elektra. He smirks at her lovingly, and asks for a smile in return.
Episode 3. aka, Many Happy Returns
On Matt's apartment rooftop, Jessica Jones stares into the face of her nightmares in Kevin Killgrave. She repeats to herself that he should be dead, and Killgrave says that he might as well have been, if not for the help of their mutual friend Mr. Degli. Stick interjects, asking who Degli really is, and Elektra says he is the one who brought her back from the dead as well. Matt tries to reach Elektra, but Killgrave confidently says she is under her control, just like the "Hero of Harlem." He directs Elektra to deal with Matt and Stick while he confronts Jessica, who immediately gets angry as he approaches and punches him as hard as she can. The punch barely fazes Killgrave, as he smiles about upgrades and grabs her by the wrist, tossing her down through a skylight into Matt's apartment. Elektra uses her twin sais to fight Stick and Murdock, holding her own despite the 2 on 1 disadvantage. Mostly this appears due to Matt continuing to try and reach her memories, though with little success. Stick fights with more reckless abandon, and nearly gets advantage of Elektra with his cane and almost pushes Elektra off the roof. Before Stick can finish her, Matt stops him, turning Stick's back to his opponent. This results in Elektra jumping back up onto the rooftop and stabbing Stick through the Chest with her sai, narrowly missing Matt in the process. This shocks Matt into fighting back with reckless abandon, though the two stalemate in their battle.
Inside the apartment, Jessica picks herself up and hides in the shadows as Kevin jumps down after her, seemingly unaffected by the fall. Killgrave boasts that Degli has "perfected his methods" and that he is now as strong as she is. Behind the kitchen island, Jessica grabs a rag and half full wine bottle, rapidly trying to make a Molotov Cocktail as Kevin continues to brag about how they'll finally be able to be together. Placing the bottle and a lighter behind her back, Jessica stands up and tells Killgrave she's not afraid of him anymore, he has no power over her. Kevin smirks and says that she is still lying to herself if she believes that, and as he gets closer, Jessica lights the bottle and tosses it at Killgrave, blinding him with the fireball before leaping over the island and dropkicking him to the floor. Jessica lets loose with right hands, trying to beat Killgrave to a pulp, but he reaches into his suit pocket and sprays mace in her face to blind her, before withdrawing out of the apartment. Hearing the commotion, a suddenly more sober Trish comes running out of the bedroom and helps Jessica. Outside, Elektra and Matt continue their fight, but Elektra hears Killgrave calling to her to leave, and she obeys him. Matt holds the dying Stick on the rooftop, and he tells Matt that Degli must be the key before passing away. Later, as Matt and Jessica regroup, Matt remembers that Killgrave mentiond the Hero of Harlem, and the two resolve to head to find Luke Cage the following morning.
However Luke Cage is still outside the Sanctum Sanctorum, trying to get in as Danny heads outside to confront him (Despite Colleen wanting to remain inside the protection of the Sanctum). Danny tries to talk sense to Luke, but Cage is undaunted and attacks Danny head on, not saying a word due to being under mind control from Killgrave (seemingly enhanced by the powers of Mordo and Degli, given the rings of Eldritch magic surrounding Luke's head.) Danny attempts simple martial arts against Luke, but all of his strikes fail, until he finally charges his ki into his fist and hits Luke with it, knocking him across the street with the force of the blow. Before Danny can go retrieve Luke, Doctor Strange tells him to come back inside. Danny explains that Luke is the "Hero of Harlem" and must be under some kind of coercion. Strange senses the magic around him and without a thought, casually breaks the spell (causing Danny to ask why he didn't do that faster, which Strange remarks that he was kind of busy.) With Luke unconscious, he is brought back into the Sanctum for healing purposes.
Elsewhere, Degli and Mordo discuss matters as they view events through mystical portals generated by the latter, with the former upset at the loss of Cage as they needed him to serve as muscle and fight against the forces of K'un-Lun. Mordo tells him not to worry, as they have alternative means of obtaining what they need to ensure their master's entry into K'un-Lun and out of his realm. After all, he reminds him, The Hand had previously decimated a lot of the Order of the Iron Fist, serving their purpose in the past. And they only need one blood sacrifice, after all. He then reveals the homeless man from the first episode, which Degli smiles at seeing, referring to him as "father". The man identifies himself as a mortal shell for the Faltine Entity Mephisto, and that it feels good to get out and "stretch his legs." Degli asks him what his plan is, and Mephisto simply smiles, telling him to be patient. They've waited this long. Right now the only thing they need to do is just keep the Iron Fist and his friends busy. He focuses on the portal containing Matt and Jessica.
Episode 4. The Dragon's Lamentation
Mordo and Degli use information obtained from Elektra to develop "evidence" to present to the proper authorities concerning the Devil of Hell's Kitchen. Elsewhere, Matt and Jessica meet up in Harlem with Claire Temple and Misty Knight, attempting to discern Luke Cage's whereabouts only to learn that he has been missing for some time. They are told a little about Luke's involvement with Degli while in prison, but before they can find out more they are attacked by NYPD officers, who arrest Matt for being in violation of the Avengers Protocols and being the masked vigilante known as Daredevil. Elsewhere, Luke is being healed at the Sanctum by Strange, with Colleen Wing being told about the mystical Book of the Vishanti, which has access to any spell contained within the vast library of Kamer-Taj and elsewhere. Luke awakens and explains what little he knows about where he was kept, and Strange tells them they need to protect the book at all costs. Colleen also asks how these Faltine can exist in their world if they are confined to their dimensions, and Strange theorizes that Blackheart has taken a host body in the form of the deceased Degli. As Colleen and Luke are transported back to Harlem, Wong asks Strange if that cost could include breaking a certain deal, and Strange refuses to consider that at the moment. Danny meets up with Ward Meachum, discovering that Degli had at one time worked for Rand Pharmaceuticals, but had died several years earlier. When Danny asks about The Hand, Meachum informs him that the Hand may have had some "weird kind of medical science stuff" going on, which Danny eventually recognizes as their resurrection capabilities. In jail, Matt consults with Foggy Nelson concerning his options, when he is approached by a specialist lawyer that Nelson contacted for his specific case...Jennifer Walters, aka She-Hulk.
Episode 5. aka, The Court Jester
Jennifer and Matt plan their defense for the upcoming extradition hearing, on whether Matt will be remanded into SHIELD custody for the violation of the Avengers Protocols. Foggy also disappears for the time being, lest he be investigated as an "accomplice" into these allegations. Meanwhile Luke meets back up with Claire Temple and Misty Knight in Harlem, also meeting Danny Rand properly this time. Claire contacts Jessica Jones, who had left her number in case Luke came back around, bringing her into the fold as well. The three discuss what they know about Degli, receiving instructions from Doctor Strange concerning where he thinks Degli and Mordo are currently holed up, somewhere near the Rand Pharmaceuticals building where The Hand was working. At the hearing, things go normally, though Luke, Danny and Jessica (asked too by Strange, who continues to look for the group while inside the Sanctum Sanctorum) are in the crowd watching proceedings. Elektra suddenly appears, egged on by Kevin Killgrave, apparently in an attempt to kill Matt Murdock. The four heroes (along with She-Hulk) unite and do battle with Elektra, as well as several cops that Killgrave "persuades" to aide their cause. However when he tries to sway the heroes, it falls on deaf ears, due to the interference of Wong, who enters the court room via a portal. He orders the four heroes through quickly (though a SHIELD agent in the room says he knows where they are going), and Jennifer quickly follows as well, as the group of heroes find themselves in Kamer-Taj. Danny asks why they aren't in the Sanctum, and Wong isn't certain, as that was where he was sending the portal. We cut back to the Sanctum and find the shields to the building having been ripped down, and Mordo, Degli, and the man housing Mephisto's spirit have now confronted Doctor Strange inside.
Episode 6. Older Gods
Strange stares down Mordo and his two accomplices, confident that he can take them out. However, Mephisto by himself (despite admitting that his human form limits his powers), is able to outclass the Sorcerer Supreme, and paired up with Blackheart and Mordo, Strange has no chance. He fights valiantly, but before long he is assaulted by the Wand of Watoomb just as Pangborn was, seemingly stripping him of his ability to use magic. Before Mordo can finish him off, the three collect the Book of the Vishanti they were after and depart, though Mordo says it is only to allow Strange to see the "bill coming due" for his arrogance. Strange vainly tries to open a portal as they leave, but the spell Mordo used keeps his powers at bay. Before long though, Wong is able to open another portal and recover Strange, restoring the shields around Kamer-Taj. As Wong sets about trying to heal Strange's injuries, the other heroes follow back into the Sanctum, each discussing amongst themselves what to do about the situation. Eventually they agree to set aside any differences they have and band together to fight this threat, although no thought is given to a sort of permanent team up.Strange is brought back to working order, although he can't channel much energy through his body at present moment. He tells Wong to prepare them all for battle in the city of K'un-Lun, as that's where Mephisto is headed. Strange himself briefly returns to Kamer-Taj, retrieving the Eye of Agamotto and telling himself that "every magic has its price." In the undisclosed location, Mordo retrieves the spell from the Book of the Vishanti and opens two portals, one to the idyllic setting of K'un-Lun and the other to Mephisto's Realm. Mephisto tells Mordo he has done well, and he sends Elektra and Killgrave into K'un-Lun to "prepare" the city for his arrival while he prepares his army of minions from his realm to enter the Earth.
Episode 7. The Dragon's Battle
In K'un-Lun, the monks are "persuaded" by Kevin Killgrave to stand down and not fight against the oncoming invasion, as Killgrave orders one to lead Elektra to the center of the city where the dimensional energies are the highest. Killgrave however is confronted by most of the heroes, namely Danny, Colleen, Luke, Jennifer and Jessica. Killgrave sets the monks to defend him, while in the center of K'un-Lun, Matt confronts Elektra and tries to reach her again, away from Killgrave's influence. Back in New York, Mordo maintains both portals as Degli begins ushering in demons from Mephisto's Realm to augment their forces, sending them through to K'un-Lun. However they are both confronted by Doctor Strange. With both portals open, Mordo is unable to use the Wand of Watoomb to try and prevent Strange from using magic again. Degli watches with some degree of bemusement as Strange and Mordo duel each other with both sorcery and hand to hand combat. In K'un-Lun, the demons have arrived and are beginning to overwhelm the heroes (even She-Hulk with her strength). In the melee, Jessica manages to break off from the group and Killgrave chases after her to another part of the city. She meets up with him and almost has another panic attack as Killgrave taunts her. However, he gets overconfident and she lures him into a trap, pretending to fall for his charms before grabbing him and snapping his neck, killing him. Danny and Colleen use their combined powers to seemingly break Killgrave's hold on the monks, turning them into helping fight the demons. In the central part of K'un-Lun, Matt and Elektra's fight continues to be ferocious, with Elektra saying that she was trained for this from youth. That she never had a choice to be anything more than this. Matt tells her he is giving her the choice now, and lays down his arms, leaving a question of if she will kill him or not. Back in New York, Mordo and Strange's fight is still at a standstill until Strange manages to steal and break the Wand of Watoomb, closing the portal to K'un-Lun. At the same time, Mephisto joins his son back in our world, angered by Mordo's failure. To keep him in this world, he needs someone to replace him in his, leading to him tossing Mordo through the portal as it closes. Degli leads his forces outside onto the streets of New York, summoning the demons in K'un-Lun and saying that they will "take the city later." In K'un-Lun, the Defenders are left to wonder what happened, before quickly being summoned back to New York by Wong. Elektra refuses to kill Matt at that moment, but refuses to stay behind with Killgrave dead, and she jumps through a portal to Parts Unknown, leaving Daredevil to join the other Defenders in returning to New York to fight more demons that have spawned throughout the city. And in the central part of it, Mephisto enters to fight with Strange, assuming his true form in the process.
Episode 8. Devil's in the Details
All hell has seemingly broken loose as demons begin to overrun New York. We here news clippings of other heroes such as the Fantastic Four, Iron Man and Spider-Man coordinating with SHIELD to contain the "recent invasion". In the central part of Manhattan, the Defenders have grouped together, near where the portal is, minus Doctor Strange, as they do battle with the demons at hand. Despite their misgivings with one another, they seemingly fight well as a team as they fall back closer to the warehouse. The demons are rallied together by Degli, who assumes the more monstrous form of Blackheart as the heroes fight together, Daredevil, Jessica and She-Hulk focusing more on the demons, while Cage, Iron Fist and Colleen confront Blackheart directly. Inside the warehouse, Doctor Strange comes face to face with Mephisto, who stands nearly two feet taller than him. After exchanging spellfire with him briefly (to no avail), Strange grimaces to himself as he realizes what he must do. As Blackheart seemingly prepares to finish off the Iron Fist, Strange reassembles the Wand of Watoomb surreptitiously and uses it to amplify the effects of the Eye of Agamotto, creating a bubble of stopped time covering most of New York City. Mephisto glances around, impressed by the "sorcerer's use of ancient weaponry" but says that it will not deter him. Strange and Mephisto fight more, with all efforts frozen outside the warehouse. Before long, the fight spills back out into the streets, and the proximity of the Time Stone within the Eye causes the Defenders and Blackheart to unfreeze as well. Joining together to take on the Faltine Entities, the Defenders rally and beat back the few demons affected by the Time Stone, while also driving Mephisto and Blackheart back near the portal. However, the two Faltine still manage to severely injure most of the Defenders. As they both monologue, Strange grabs the Wand of Watoomb again as well as the forgotten Book of the Vishanti. He hopes and prays to turn to the right spell, casting the incantation to close the portal to Mephisto's realm as well as casting a spell to drive them both back where they came. There is a tense moment as the demons are sucked back into the realm, time reversing in on itself to undo everything that had been done in the last 24 hours in New York, as Mephisto and Blackheart are left powerless to stop their plans from being undone.
In the aftermath, the Defenders go their separate ways, unable to reconcile Strange's power for the greater good (having undone the memories of everyone else outside their group, thanks to the power of the Time Stone augmented by the Wand of Watoomb.) Matt's identity is secret once again, as he visits Karen Page in the hospital. Luke reunites with Claire and Misty Knight in Harlem, as Danny introduces himself and Colleen and speaks of "a detective agency." Jessica returns to her own office, getting a note of "rent being due" and sees the unfinished report on the Devil of Hell's Kitchen on her desk before throwing it in the garbage (though it is also revealed that Trish has photos of the night they were in Matt's apartment, as she is called in to her radio show to do an interview with Wilson Fisk.) Jennifer returns to her life as a lawyer/hero for SHIELD, again filing a petition with SHIELD for information on the planet her cousin was sent to. Strange places the Eye of Agamotto back in Kamer-Taj, Wong pointing out that he had broken his deal with Dormammu, opening the Earth back up to his invasion in the future. Strange merely again replies that there is always a price to magic.Wong asks if the Defenders will ever stand again, and all he can say is that time will tell.
- Charlie Cox as Matt Murdock/Daredevil- A blind lawyer by day who acts as a vigilante in the streets of Hell's Kitchen thanks to enhanced senses from a childhood accident.
- Mike Colter as Luke Cage- A wrongly convicted man who seeks to right wrongs in his Native Harlem. Has indestructible skin and super strength due to a prison experiment by the mysterious Mr. Degli. Currently under the mind control of one Kevin Killgrave.
- Krysten Ritter as Jessica Jones- A Manhattan Private Eye with a drinking problem who has super strength and durability, as well as suffering from PTSD due to a previous association with Kevin Killgrave.
- Finn Jones as Daniel "Danny" Rand/Iron Fist- Heir to the Rand Pharmaceutical corporation who was raised by the monks of K'un-Lun to act as the Immortal Iron Fist. A master martial artist who can channel his ki into his fist for highly destructive power.
- Benedict Cumberbatch as Dr. Stephen Strange- A former neurosurgeon who became the Sorcerer Supreme of Earth and a master of the Mystic Arts. Unites the Defenders to counter the threat posed by Mephisto's incursions.
- Gina Carano as Jennifer Walters/She-Hulk- A former New York prosecutor who now acts as a defense lawyer for super powered individuals. Has gamma infused strength and durability due to a blood transfusion from her cousin, Bruce Banner aka The Hulk.
- Rosario Dawson as Claire Temple- A nurse who helps heal vigilantes in her off hours. Is also the girlfriend of Luke Cage.
- Simone Massick as Misty Knight- A former NYPD cop who carries on Luke Cage's work as a neighborhood activist in his absence.
- Elden Henson as Franklin "Foggy" Nelson- The law partner of Matt Murdock, who is also aware of his identity as Daredevil.
- Rachel Taylor as Patricia "Trish" Walker- The adopted sister of Jessica Jones, who may or may not have developed powers of her own in recent times.
- Scott Glenn as Stick- A blind mercenary who fought against The Hand on behalf of the city of K'un-Lun. Also trained Matt Murdock in the use of his powers.
- Jessica Henwick as Colleen Wing- A martial artist and partner to Danny Rand who gained her own powers of the Iron Fist.
- Benedict Wong as Wong- The librarian at Kamer-Taj and right hand man of Doctor Strange. Also a member of the Masters of the Mystic Arts.
- Tom Pelphrey as Ward Meachum- The current CEO of Rand Pharmaceuticals.
- Sam Witwer as Mr. Degli/Blackheart- A mysterious scientist revealed to be the son of the Faltine entity Mephisto.
- David Tennant as Kevin Killgrave- A figure from Jessica Jones past who has incredible powers of persuasion and mind control. Serves as a "general" in Blackheart's force.
- Chiwetel Ejiofor as Baron Karl Mordo- A former member of the Masters of the Mystic Arts who now serves Mephisto to his own ends.
- Elodie Young as Elektra Natchios- A ninja and former lover of Matt Murdock, resurrected by Degli/Mordo to serve as a general in Blackheart's army.
- Al Pacino as Mephisto- A Faltine Lord of his own dimension who seeks to conquer our world by seizing control of the dimensional nexus of K'un-Lun.
In addition, Vincent D'Onofrio briefly appears as Wilson Fisk/Kingpin. Deborah Ann Woll also appears as Karen Page, though she is still in a coma following the events of season 2 of Daredevil. Benjamin Bratt also briefly appears as Jonathan Pangborn.