During a test on spiders he was bitten by a radioactive one. Nick was taken to a hospital to be treated. After his visit he was sent home, when he got there he started feeling dizzy. He passed out in three minutes, when he woke up he was changed. He was muscular, and he could shoot webs. He decided to take a stroll around town, he found a person being mugged and stopped the mugger. The victim thanked him and asked who was, he responded, "I'm Spider Man." He later created a suit to be remembered in.
Nick continued his testing on spiders, his partner Martin Noll, tested on lizards. One day while alone in his lab Martin injected himself with lizard DNA. He was testing if humans could be more like reptiles, something went wrong and he became a monster. The monster was driven by massacre, and had a liking for human flesh. Spider man was patrolling the city when he saw the monster. It was terrorizing a group of civilians, he fought the monster. The best was stronger than him, he was slashing the bug. Finally Nick knocked out the creature and read the name tag on it's coat. He knew it was Noll, but Noll's creature instincts drove him to kill Nick. The fight continued Martin, Martin and Nick climbed to the top of the Empire State building. Martin was pushed off and fell to the ground, Nick spat at the monster.