During a field trip to his friend Harry's father's company, Osborn Industries, Peter met a new class-mate, Gwen Stacy, whom he has taken a romantic interest in. Later that same day, Peter was bitten by a radioactive spider at Osborn Industries, making him extremely ill. The spider had been experimented on with the "Globulin Formula", which was Osborn Industries' attempt at recreating the Super Soldier Serum used to create Captain America. The bite forced him to pass out, and the very next day, he discovered that he had new powers and abilities, similar to those of a spider.
The day after he was bitten by the spider, Peter got into a big argument with his Uncle Ben, leaving Ben very upset. Feeling bad, Peter went home to talk with Ben, only to find that he had been brutally murdered.
- Peter Parker is 15 years old at the time of his first appearance, in Spider-Man: Genesis Vol 1 1. It isn't known whether he had already turned 15 that year (2018) or if he hadn't yet had his birthday for that year, making it unclear if he was born in 2002 or 2003.