Board Thread:General Discussion/@comment-2058272-20161012193901/@comment-29421682-20161016205230

The main villain would be the Lizard. The film's plot would revolve around Curt Connors (Peter and Felicia's biology professor) trying to develop a cure for vascular disease and the walking dead, the former of which cost him his right arm. In order to do this, however, he extracts the DNA from several different types of reptiles (komodo dragons, crocodiles, gila monsters, salamanders, etc.) in order to create a regenerative substance that would, in theory, be able to regrow lost limbs after surgical seperation. Due to the amount of venom found in the blood of gila monsters, Connors genetically modifies it's structure in order to allow safe passage into the human body. He then tests it on himself in order to regrow his arm. The experiment works, but at a cost. Over the course of the next few days, Connors rapidly becomes less and less human. Flesh becomes scales, nails become claws, he grows a tail, etc. Peter tries to check up on the professor one evening, only for Connors, now completely transformed into the Lizard, escapes and rampages throughout Manhattan, only to be stopped by Spider-Man. In the ensuing battle, the Lizard escapes and heads for Oscorp Industries, of which he was a former employee of. The Lizard, believing that the only way to save humanity is to eradicate it, steals samples of an earlier version of the regeneration formula. He then places the serum into the city's water supply via the sewer. Within the following week, over 53% of the city's population has been transformed into giant lizards. The National Guard and S.H.I.E.L.D. are called in in order to handle the situation. Several heroes, such as Spider-Man, Iron Man, Captain America, Scarlet Witch, and Quicksilver, have formed a resistance in order to get as many lives to safety as possible and to help S.H.I.E.L.D. cleanse the problem. Eventually, Spider-Man leaves the group in order to find the Lizard. Spider-Man and the Lizard battle in Madison Square Garden, where Curt Connors eventually regains control of himself and manages to revert back to normal. Connors then activates a last resort gas grenade which contains the vaccine via the city's ventilation system, causing everyone to revert back to human. Weeks later, Manhattan is fully recovered and Spider-Man is given an Avengers ID card with a note from Iron Man stating that Spider-Man is now the first official reserve member of the Avengers.

The film's post-credits would feature a shot of Norman Osborn, a victim of the Lizard's gas, sitting in Oscorp Tower, recovering from the virus. Norman then looks over at his collection of masks as he lays his eyes on a goblin mask, giving off an evil smile as he does so.